November 18, 2011

Research Highlights

During the past 10 years, scientific contributions produced by DLab range from developments in applied to pure research. The following are the most significant contributions to date.

Identifying the Fusion Protein of Hanta Virus

In 2005, in collaboration with Dr. Pablo DT Valenzuela and Dr. Nicole Tishler (Fundación Ciencia para la Vida) we proposed that the Hantavirus Gc glycoprotein is the Hantavirus fusion protein, thus opening novel therapeutical targets for the hanta virus pulmonary disease.


Novel HIV-RT 1 Non-nucleoside Inhibitors

In 2007, in collaboration with Dr. David Pezoa (Universidad Católica de Chile), we designed novel non-nucleoside inhibitors suitable to be used as drugs for the HIV treatment.


Mathematical Models for Drug Design

In 2008, we proposed a new mathematical model suitable to predict the biological activity of non-nucleoside HIV-RT 1 inhibitors.

Protein Engineering

In 2008, in collaboration wirth Dr. Jaime Eyzaguirre (Universidad Andrés Bello), we used molecular modeling and molecular simulation tools to expand the sustrate specificity of an Axe II enzime.

Functional Microdomains in CB receptor

In 2008, we proposed that CB receptors are organized in 4 different compartments: the extracellular and the intracellular domains, and the aromatic and polar microdomains. Thus different ligands, both polar and aromatic ones, can be recognized by the same tridimensional architecture of proteins.


Enabling Personalized Medicine

In 2008, in collaboration with Dr. Carlos Fardella (Facultad de Medicina, PUC), we used molecular modeling and simulation tools to explain the molecular-level effects of a single nucleotide polymorphism that affected MC2R receptor.


Studying the Water Transport Phenomenon Across Membranes

We have recently proposed that archeal aquaporin such as AqpM belongs to a third class of aquaporins.

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