Welcome to the Computational Biology Lab @ CMM

The Computational Biology Lab (DLab) is a transdisciplinary laboratory for applied-research located at the Center for Mathematical Modeling (CMM) at the School of Engineering and Sciences, University of Chile.

Research Focus
Headed by Dr. Tomas Perez-Acle, the main objective of DLab is to produce multiscale computational models to explain complex biological phenomena. To do so, we use tools coming from mathematical modeling and high performance computing (HPC). At the microscale (atomic), we use molecular modeling and molecular simulations to understand the fundamental properties that govern biological processes such as intercellular communication, membrane transport and molecular recognition. At the meso and macroscale, we use rule-based modeling and network topology to produce  and characterize stochastic simulations of cell signaling, gene regulation and infectious diseases.

In general, researchers and graduate students work in:

Molecular Design
  • Molecular modeling and molecular simulations
  • Protein engineering
  • Computer-based drug design
  • Nanobiotechnology
Complex Systems
  • Network topology
  • Stochastic modeling
  • Rule-based modeling
  • Formal languages (kappa)
DLab members come from different fields such as mathematics, engineering, biology, biochemistry, microbiology and biotechnology. In our transdisciplinary environment, every project is carried out by a team of people with diverse and complementary backgrounds. In this atmosphere, discussion and rigorousity is always sought, with a touch of brotherhood, friendship and collaborative research.

Scientific and technological contributions
For more than 10 years, students and researchers working at DLab contributed with applications in science and technology. DLab’s scientific papers and patents can be found here.